Preview Articles

Mononucleosis—Child Care and Schools

2026-03-31

Version:

0.2
Active

What is mononucleosis?

Mononucleosis (widely known as mono ) is a disease most commonly caused by the Epstein-Barr virus (also called EBV or human herpesvirus 4 ) and sometimes by other viruses such as cytomegalovirus (human herpesvirus 5) and roseola (human herpesvirus 6).

What are the signs or symptoms?

  • Usually mild or no signs or symptoms, especially in young children

  • Fever

  • Sore throat

  • Fatigue and malaise

  • Swollen lymph nodes

  • Temporary enlargement of the liver and spleen for several weeks

  • Rash may occur with those treated with amoxicillin or other penicillin antibiotics. This rash is not an allergy to the antibiotic.

What are the incubation and contagious periods?

  • Incubation period: Estimated to be 30 to 50 days for EBV.

  • Contagious period: Virus is excreted for many months after infection, and virus shedding can occur intermittently throughout life.

How is it spread?

Person-to-person contact

  • Kissing on the mouth

  • Sharing objects contaminated with saliva (eg, toys, toothbrushes, cups, bottles)

  • Semen during sexual contact

  • May be spread by blood transfusion or organ transplant

How do you control it?

  • Use good hand-hygiene technique at all the times listed in Chapter 2 of Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide, 7th Edition .

  • Avoid transfer or contact with saliva (eg, through kissing or sharing respiratory secretions directly or through contact with objects like food utensils, cups, soda cans, and bottles of water).

  • People with signs and symptoms of mononucleosis should not donate blood.

Swollen lymph nodes in a 7-year-old with infectious mononucleosis

AMERICAN ACADEMY OF PEDIATRICS

Profile view of a child's right face, ear, and neck, showing raised round swelling in the jawline and upper neck area, about the size of a baseball, indicating swollen lymph nodes.

What are the roles of the educator and the family?

  • Clean or sanitize surfaces that are touched by hands frequently, such as toys, tables, and doorknobs, according to the Routine Schedule for Cleaning, Sanitizing, and Disinfecting in Chapter 8 of Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide, 7th Edition .

  • Ensure all children have their own toothbrushes, cups, and eating utensils.

  • Prevent children from sharing food.

  • Avoid kissing children on the mouth.

Exclude from educational setting?

No, unless

  • The child is unable to participate and staff members determine they cannot care for the child without compromising their ability to care for the health and safety of the other children in the group.

  • The child meets other exclusion criteria (see Conditions Requiring Temporary Exclusion in Chapter 4 of Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide, 7th Edition ).

Readmit to educational setting?

Yes, when all the following criteria are met:

  • When exclusion criteria are resolved, the child is able to participate, and staff members determine they can care for the child without compromising their ability to care for the health and safety of the other children in the group.

  • School-aged children and adolescents should avoid strenuous activity and contact sports for at least 4 to 6 weeks after symptoms start as the spleen may temporarily enlarge and is at risk of rupture with physical impact. Clearance for contact sports will depend on a health practitioner’s assessment of ongoing symptoms and size of the spleen. It may take 3 to 6 months or longer for a child to regain their full stamina, strength, and fitness.

Comments

  • Most people get the infection in early childhood when signs or symptoms are mild and the disease goes undiagnosed.

  • However, rarely, the disease can be severe, particularly in adolescents. Some individuals might experience ongoing symptoms, such as significant fatigue or malaise, fever, muscle aches, or cognitive fog. These individuals may benefit from class modifications such as adjusted assignments, extended deadlines, or remote learning, depending on the severity of their symptoms.

  • General exclusion of those with mononucleosis is not practical.

Disclaimer

Adapted from Managing Infectious Diseases in Child Care and Schools: A Quick Reference Guide , 7th Edition.

The American Academy of Pediatrics (AAP) is an organization of 67,000 primary care pediatricians, pediatric medical subspecialists, and pediatric surgical specialists dedicated to the health, safety, and well-being of all infants, children, adolescents, and young adults.

Any websites, brand names, products, or manufacturers are mentioned for informational and identification purposes only and do not imply an endorsement by the American Academy of Pediatrics (AAP). The AAP is not responsible for the content of external resources. Information was current at the time of publication. The information contained in this publication should not be used as a substitute for the medical care and advice of your pediatrician. There may be variations in treatment that your pediatrician may recommend based on individual facts and circumstances.

Copyright © American Academy of Pediatrics Date Updated: 2026-03-31T04:26:36.859Z Version 0.2

Powered by RemedyConnect. Please read our disclaimer.

Changes from the previous version.

The latest version shifts from a concise child-care guidance sheet to a more current, clinically nuanced educational resource. It uses updated terminology and framing, adds practical detail about symptom duration, transmission, and return-to-activity decisions, and places greater emphasis on individualized management rather than simple exclusion. The current standard also broadens the audience from “teacher/caregiver” to “educator and family,” reflecting a more inclusive, school-based public health approach. - Rash guidance is updated: amoxicillin is named specifically, and the rash is clarified as not being an antibiotic allergy. - Transmission information now includes semen during sexual contact, expanding beyond saliva and blood/organ exposure. - Control measures are updated to reference the 7th Edition and specific cleaning/sanitizing schedules for high-touch surfaces. - Return-to-setting guidance is more detailed, especially for school-aged children and adolescents, with a 4–6 week avoidance of strenuous activity/contact sports and clinician-based clearance. - Comments now acknowledge prolonged symptoms (fatigue, malaise, fever, muscle aches, cognitive fog) and suggest classroom accommodations such as adjusted assignments, extended deadlines, or remote learning.